Gene-Gene Interaction Analysis in Alzheimer
نویسندگان
چکیده
منابع مشابه
Exploiting gene × gene interaction in linkage analysis
When two genes interact to cause a clinically important phenotype, it would seem reasonable to expect that we could leverage genotypic information at one of the loci in order to improve our ability to detect the other. We were therefore interested in extending the posterior probability of linkage (PPL), a class of linkage statistics we have been developing over the past decade, in order to expl...
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Genome-wide association studies (GWAS) have successfully discovered hundreds of associations between genetic variants and complex traits. Most GWAS have focused on the identification of single variants. It has been shown that most of the variants that were discovered by GWAS could only partially explain disease heritability. The explanation for this missing heritability is generally believed to...
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BACKGROUND Although some genes associated with increased risk of Alzheimer Disease (AD) have been identified, few data exist related to gene/gene and gene/environment risk of AD. The purpose of this pilot study was to explore gene/gene and gene/environment associations in AD and to obtain data for sample size estimates for larger, more definitive studies of AD. METHODS The effect of gene/gene...
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ژورنال
عنوان ژورنال: International Journal of Computer Science and Information Technology
سال: 2018
ISSN: 0975-4660,0975-3826
DOI: 10.5121/ijcsit.2018.10307